Islands of runs of homozygosity indicate selection signatures in Ovis aries 6 (OAR6) of French dairy sheep
Silvia Teresa Rodríguez‐Ramilo, Antônio Reverter, Andrés Legarra
Abstract
The occurrence of runs of homozygosity (ROH) is not randomly distributed across the genome, and ROH islands across many animals may be the result of selective pressure. The objective of this study was to demonstrate that the presence of ROH islands may be indicative of selection signatures in French dairy sheep breeds and subpopulations. One island of ROH was detected on OAR6 in the same genomic position across animals (between 30 and 40 Mb). Global Wright's differentiation coefficients (F ST ) for 2 SNP (OAR6_41583796.1 and OAR6_41709987.1) within this ROH island were high (0.67-0.68). ROH and single SNP FST analyses agreed that selection signatures exist around both SNP that were located near the NCAPG and LCORL genes.