Discovery of Novel and Highly Potent Resorcinol Dibenzyl Ether-Based PD-1/PD-L1 Inhibitors with Improved Drug-like and Pharmacokinetic Properties for Cancer Treatment
Binbin Cheng, Wei Wang, Xiaoge Niu, Yichang Ren, Ting Liu, Hao Cao, Shuanghu Wang, Yingfeng Tu, Jingxuan Chen, Shuwen Liu, Xuchao Yang, Jianjun Chen
Abstract
represents a promising PD-1/PD-L1 inhibitor worthy of further investigation as a potential anticancer agent.
Topics & Concepts
ChemistryPharmacokineticsResorcinolEtherDrugPharmacologyDrug discoveryCombinatorial chemistryStereochemistryOrganic chemistryBiochemistryMedicineCancer Immunotherapy and BiomarkersPeptidase Inhibition and AnalysisSynthesis and Biological Evaluation