Exploring Emergent Properties in Enzymatic Reaction Networks: Design and Control of Dynamic Functional Systems
Souvik Ghosh, Mathieu G. Baltussen, Nikita M. Ivanov, Rianne Haije, Miglė Jakštaitė, Tao Zhou, Wilhelm T. S. Huck
Abstract
enables stepwise build up in complexity and introduces the opportunity to control enzymatic activity using physicochemical stimuli. Rational design and modulation of network motifs enable the engineering of artificial systems with emergent functionalities. Such functional systems are useful for a variety of reasons such as creating new-to-nature dynamic materials, producing value-added chemicals, constructing metabolic modules for synthetic cells, and even enabling molecular computation. In this review, we offer insights into the chemical characteristics of ERNs while also delving into their potential applications and associated challenges.