Docetaxel-loaded exosomes for targeting non-small cell lung cancer: preparation and evaluation <i>in vitro</i> and <i>in vivo</i>
Ying Wang, Mimi Guo, Dingmei Lin, Dajun Liang, Ling Zhao, Ruizhi Zhao, Yan Wang
Abstract
evaluation and showed better targeting to tumor tissue compared to the free DTX in the mice. We also explored the potential of tumor cell-derived exosomes as a drug delivery agent to target the parent cancer. Hence, we conclude that exosomes might be used as a potential antitumor drug delivery system (DDS).
Topics & Concepts
In vivoDocetaxelMicrovesiclesCytotoxicityCancer researchApoptosisDrug deliveryIn vitroLung cancerCancer cellNanocarriersPharmacologyChemistryMedicineCancerMaterials scienceBiologyDrugOncologyInternal medicineNanotechnologyBiochemistryBiotechnologymicroRNAGeneExtracellular vesicles in diseaseMicroRNA in disease regulationInhalation and Respiratory Drug Delivery