Impact of tail unsaturation in ionizable lipids on mRNA delivery efficiency and immunogenicity of lipid nanoparticles
Xueer Ge, Zepeng He, Haihong Yang, Xiaorong Pan, Liang Yan, Yi Shi, Yongming Chen, Zhijia Liu
Topics & Concepts
ImmunogenicityDegree of unsaturationChemistryRational designEndosomeNanocarriersIn vivoBiophysicsMessenger RNABiochemistryDrug deliveryNanotechnologyBiologyAntigenImmunologyOrganic chemistryMaterials scienceReceptorBiotechnologyGeneRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesViral Infections and Immunology Research